NIACIN I.P/B.P
NIACIN I.P/B.P
SPECIFICATION FOR NIACINAMIDE (NICOTINAMIDE) I.P.
| Name Of Finished Product | Nicotinamide |
| Molecular Formula | C6H6N2O |
| Molecular Weight | 122.12 |
| Packing | 20 Kgs & 25 Kgs |
| The Shelf-Life | 5 Years |
| Storage Conditions And Precautions | Store In A Well-Closed Containers. |
| NO | TEST | OBSERVATION |
|---|---|---|
| 1 | Description | Colourless Crystals Or A White Crystalline Powder; Odourless And Bitter Taste. |
| 2 | Solubility | Freely Soluble In Water, Ethanol (95%), & Slightly Soluble In Diethyl Ether. |
| 3 | Identification | Test A May Be Omitted If Tests B, C &D Are Carried Out. Tests B, C And D May Be Omitted If Tests A Is Carried Out. A. Determine By Infrared Absorption Spectrophotometry. Compare The Spectrum With That Obtained With Nicotinamide RS Or With The Reference Spectrum Of Nicotinamide. B. Heat About 5 Mg In A Dry Tube; Pyridine Is Evolved. C. Boil 0.1 G With 10 Ml Of Dilute Sodium Hydroxide Solution; Ammonia Is Evolved. D. To 2 Ml Of A 0.1% W/V Solution Add 6 Ml Of Cyanogen Bromide Solution And 1 Ml Of A 2.5% W/V Solution Of Aniline; A Golden Yellow Colour Develops. |
| 4 | Appearance Of Solution | A 5% W/V Solution In Carbon Dioxide-Free Water Is Clear, And Not More Intensely Coloured That Reference Solution. |
| 5 | Chloride | Not More Than 250 Ppm. |
| 6 | Sulphate | 1.2 G Complies With The Limit Test For Sulphates (125 Ppm). |
| 7 | Related Substances | Not More Than 0.2 %. |
| 8 | Sulphated Ash | Not More Than 0.1% |
| 9 | Assay, W/W | 98.5 – 101.0% |
| 10 | Heavy Metals | Not More Than 30 Ppm |